NUDCD3 Back

NudC domain containing 3

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NCBI Description of NUDCD3
The product of this gene functions to maintain the stability of dynein intermediate chain. Depletion of this gene product results in aggregation and degradation of dynein intermediate chain, mislocalization of the dynein complex from kinetochores, spindle microtubules, and spindle poles, and loss of gamma-tubulin from spindle poles. The protein localizes to the Golgi apparatus during interphase, and levels of the protein increase after the G1/S transition.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NUDCD3 is highly significantly mutated in
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NUDCD3 is significantly mutated in
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NUDCD3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NUDCD3