neutral sphingomyelinase (N-SMase) activation associated factor

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NCBI Description of NSMAF

This gene encodes a WD-repeat protein that binds the cytoplasmic sphingomyelinase activation domain of the 55kD tumor necrosis factor receptor. This protein is required for TNF-mediated activation of neutral sphingomyelinase and may play a role in regulating TNF-induced cellular responses such as inflammation. Alternative splicing results in multiple transcript variants.

Community Annotation of NSMAF Add / Edit NSMAF: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NSMAF is highly significantly mutated in
NSMAF is significantly mutated in
NSMAF is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NSMAF