NSL1 Back

NSL1, MIND kinetochore complex component, homolog (S. cerevisiae)

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NCBI Description of NSL1

This gene encodes a protein with two coiled-coil domains that localizes to kinetochores, which are chromosome-associated structures that attach to microtubules and mediate chromosome movements during cell division. The encoded protein is part of a conserved protein complex that includes two chromodomain-containing proteins and a component of the outer plate of the kinetochore. This protein complex is proposed to bridge centromeric heterochromatin with the outer kinetochore structure. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NSL1 Add / Edit NSL1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NSL1 is highly significantly mutated in
NSL1 is significantly mutated in
NSL1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NSL1