NRGN Back

neurogranin (protein kinase C substrate, RC3)

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NRGN
Neurogranin (NRGN) is the human homolog of the neuron-specific rat RC3/neurogranin gene. This gene encodes a postsynaptic protein kinase substrate that binds calmodulin in the absence of calcium. The NRGN gene contains four exons and three introns. The exons 1 and 2 encode the protein and exons 3 and 4 contain untranslated sequences. It is suggested that the NRGN is a direct target for thyroid hormone in human brain, and that control of expression of this gene could underlay many of the consequences of hypothyroidism on mental states during development as well as in adult subjects.

Community Annotation of NRGN Add / Edit NRGN: Annotations

No community annotations yet for NRGN.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NRGN is highly significantly mutated in
(none)
NRGN is significantly mutated in
(none)
NRGN is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NRGN