NR4A2 Back

nuclear receptor subfamily 4, group A, member 2

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NCBI Description of NR4A2

This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. The encoded protein may act as a transcription factor. Mutations in this gene have been associated with disorders related to dopaminergic dysfunction, including Parkinson disease, schizophernia, and manic depression. Misregulation of this gene may be associated with rheumatoid arthritis. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NR4A2 is highly significantly mutated in
NR4A2 is significantly mutated in
NR4A2 is near significance in
8 patients (3%)

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NR4A2