NR4A1 Back

nuclear receptor subfamily 4, group A, member 1

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NCBI Description of NR4A1
This gene encodes a member of the steroid-thyroid hormone-retinoid receptor superfamily. Expression is induced by phytohemagglutinin in human lymphocytes and by serum stimulation of arrested fibroblasts. The encoded protein acts as a nuclear transcription factor. Translocation of the protein from the nucleus to mitochondria induces apoptosis. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NR4A1 is highly significantly mutated in
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NR4A1 is significantly mutated in
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NR4A1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NR4A1