NR2C1 Back

nuclear receptor subfamily 2, group C, member 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NR2C1
This gene encodes a nuclear hormone receptor characterized by a highly conserved DNA binding domain (DBD), a variable hinge region, and a carboxy-terminal ligand binding domain (LBD) that is typical for all members of the steroid/thyroid hormone receptor superfamily. This protein also belongs to a large family of ligand-inducible transcription factors that regulate gene expression by binding to specific DNA sequences within promoters of target genes. Multiple alternatively spliced transcript variants have been described, but the full-length nature of some of these variants has not been determined.

Community Annotation of NR2C1 Add / Edit NR2C1: Annotations

No community annotations yet for NR2C1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NR2C1 is highly significantly mutated in
(none)
NR2C1 is significantly mutated in
(none)
NR2C1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NR2C1