NCBI Description of NR1H4
|This gene encodes a ligand-activated transcription factor, which shares structural features in common with nuclear hormone receptor family, such as a DNA-binding domain that targets the receptor to specific DNA sequences, and a ligand-binding domain, which interacts directly with the ligand and contains a ligand-dependent transcriptional activation domain. This protein functions as a receptor for bile acids, and when bound to bile acids, regulates the expression of genes involved in bile acid synthesis and transport. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.|
Community Annotation of NR1H4 Add / Edit NR1H4: Annotations
No community annotations yet for NR1H4.
• "Mouse over" a mutation to see details.
Click on a tumor type to see its full list of significant genes.