NPR3 Back

natriuretic peptide receptor C/guanylate cyclase C (atrionatriuretic peptide receptor C)

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NCBI Description of NPR3
This gene encodes one of three natriuretic peptide receptors. Natriutetic peptides are small peptides which regulate blood volume and pressure, pulmonary hypertension, and cardiac function as well as some metabolic and growth processes. The product of this gene encodes a natriuretic peptide receptor responsible for clearing circulating and extracellular natriuretic peptides through endocytosis of the receptor. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NPR3 Add / Edit NPR3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NPR3 is highly significantly mutated in
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NPR3 is significantly mutated in
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NPR3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NPR3