NPR2 Back

natriuretic peptide receptor B/guanylate cyclase B (atrionatriuretic peptide receptor B)

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NCBI Description of NPR2
This gene encodes natriuretic peptide receptor B, one of two integral membrane receptors for natriuretic peptides. Both NPR1 and NPR2 contain five functional domains: an extracellular ligand-binding domain, a single membrane-spanning region, and intracellularly a protein kinase homology domain, a helical hinge region involved in oligomerization, and a carboxyl-terminal guanylyl cyclase catalytic domain. The protein is the primary receptor for C-type natriuretic peptide (CNP), which upon ligand binding exhibits greatly increased guanylyl cyclase activity. Mutations in this gene are the cause of acromesomelic dysplasia Maroteaux type.

Community Annotation of NPR2 Add / Edit NPR2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NPR2 is highly significantly mutated in
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NPR2 is significantly mutated in
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NPR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NPR2