NOXA1 Back

NADPH oxidase activator 1

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NCBI Description of NOXA1
This gene encodes a protein which activates NADPH oxidases, enzymes which catalyze a reaction generating reactive oxygen species. The encoded protein contains four N-terminal tetratricopeptide domains and a C-terminal Src homology 3 domain. Interaction between the encoded protein and proteins in the oxidase regulatory complex occur via the tetratricopeptide domains. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NOXA1 is highly significantly mutated in
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NOXA1 is significantly mutated in
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NOXA1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NOXA1