NOD2 Back

nucleotide-binding oligomerization domain containing 2

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NCBI Description of NOD2
This gene is a member of the Nod1/Apaf-1 family and encodes a protein with two caspase recruitment (CARD) domains and six leucine-rich repeats (LRRs). The protein is primarily expressed in the peripheral blood leukocytes. It plays a role in the immune response to intracellular bacterial lipopolysaccharides (LPS) by recognizing the muramyl dipeptide (MDP) derived from them and activating the NFKB protein. Mutations in this gene have been associated with Crohn disease and Blau syndrome.

Community Annotation of NOD2 Add / Edit NOD2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NOD2 is highly significantly mutated in
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NOD2 is significantly mutated in
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NOD2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NOD2