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NOBOX oogenesis homeobox

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NCBI Description of NOBOX
This homeobox gene encodes a transcription factor that is thought to play a role in oogenesis. In mice, it is essential for folliculogenesis and regulation of oocyte-specific genes. Defects in this gene result in premature ovarian failure type 5. Sequence Note: The RefSeq transcript and protein were assembled by in silico methods based on partial sequence data reported in PMID: 16597639 and additional support from similarity to mouse protein NP_570939.1. The 5' and 3' exons have not been experimentally verified in humans.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NOBOX is highly significantly mutated in
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NOBOX is significantly mutated in
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NOBOX is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NOBOX