NMT1 Back

N-myristoyltransferase 1

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NMT1
Myristate, a rare 14-carbon saturated fatty acid, is cotranslationally attached by an amide linkage to the N-terminal glycine residue of cellular and viral proteins with diverse functions. N-myristoyltransferase (NMT; EC 2.3.1.97) catalyzes the transfer of myristate from CoA to proteins. N-myristoylation appears to be irreversible and is required for full expression of the biologic activities of several N-myristoylated proteins, including the alpha subunit of the signal-transducing guanine nucleotide-binding protein (G protein) GO (GNAO1; MIM 139311) (Duronio et al., 1992 [PubMed 1570339]).[supplied by OMIM, Nov 2008].

Community Annotation of NMT1 Add / Edit NMT1: Annotations

No community annotations yet for NMT1.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NMT1 is highly significantly mutated in
(none)
NMT1 is significantly mutated in
(none)
NMT1 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NMT1