NMNAT3 Back

nicotinamide nucleotide adenylyltransferase 3

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NCBI Description of NMNAT3
This gene encodes a member of the nicotinamide/nicotinic acid mononucleotide adenylyltransferase family. These enzymes use ATP to catalyze the synthesis of nicotinamide adenine dinucleotide or nicotinic acid adenine dinucleotide from nicotinamide mononucleotide or nicotinic acid mononucleotide, respectively. The encoded protein is localized to mitochondria and may also play a neuroprotective role as a molecular chaperone. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.

Community Annotation of NMNAT3 Add / Edit NMNAT3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NMNAT3 is highly significantly mutated in
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NMNAT3 is significantly mutated in
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NMNAT3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NMNAT3