nicotinamide nucleotide adenylyltransferase 2

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NCBI Description of NMNAT2

This gene product belongs to the nicotinamide mononucleotide adenylyltransferase (NMNAT) enzyme family, members of which catalyze an essential step in NAD (NADP) biosynthetic pathway. Unlike the other human family member, which is localized to the nucleus, and is ubiquitously expressed; this enzyme is cytoplasmic, and is predominantly expressed in the brain. Two transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NMNAT2 Add / Edit NMNAT2: Annotations

No community annotations yet for NMNAT2.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NMNAT2 is highly significantly mutated in
NMNAT2 is significantly mutated in
NMNAT2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NMNAT2