NMNAT1 Back

nicotinamide nucleotide adenylyltransferase 1

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NCBI Description of NMNAT1
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NMNAT1 is highly significantly mutated in
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NMNAT1 is significantly mutated in
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NMNAT1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NMNAT1