NLRP2 Back

NLR family, pyrin domain containing 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NLRP2
NALP proteins, such as NALP2, are characterized by an N-terminal pyrin (MIM 608107) domain (PYD) and are involved in the activation of caspase-1 (CASP1; MIM 147678) by Toll-like receptors (see TLR4; MIM 603030). They may also be involved in protein complexes that activate proinflammatory caspases (Tschopp et al., 2003 [PubMed 12563287]).[supplied by OMIM, Mar 2008].

Community Annotation of NLRP2 Add / Edit NLRP2: Annotations

No community annotations yet for NLRP2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NLRP2 is highly significantly mutated in
(none)
NLRP2 is significantly mutated in
(none)
NLRP2 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NLRP2