NKX6-1 Back

NK6 homeobox 1

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NCBI Description of NKX6-1
In the pancreas, NKX6.1 is required for the development of beta cells and is a potent bifunctional transcription regulator that binds to AT-rich sequences within the promoter region of target genes Iype et al. (2004) [PubMed 15056733].[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NKX6-1 is highly significantly mutated in
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NKX6-1 is significantly mutated in
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NKX6-1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NKX6-1