NKX3-1 Back

NK3 homeobox 1

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NCBI Description of NKX3-1

This gene encodes a homeobox-containing transcription factor. This transcription factor functions as a negative regulator of epithelial cell growth in prostate tissue. Aberrant expression of this gene is associated with prostate tumor progression. Alternate splicing results in multiple transcript variants of this gene.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NKX3-1 is highly significantly mutated in
NKX3-1 is significantly mutated in
NKX3-1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NKX3-1