NHEJ1 Back

nonhomologous end-joining factor 1

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NCBI Description of NHEJ1
Double-strand breaks in DNA result from genotoxic stresses and are among the most damaging of DNA lesions. This gene encodes a DNA repair factor essential for the nonhomologous end-joining pathway, which preferentially mediates repair of double-stranded breaks. Mutations in this gene cause different kinds of severe combined immunodeficiency disorders.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NHEJ1 is highly significantly mutated in
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NHEJ1 is significantly mutated in
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NHEJ1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NHEJ1