NGLY1 Back

N-glycanase 1

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NCBI Description of NGLY1
This gene encodes an enzyme that catalyzes hydrolysis of an N(4)-(acetyl-beta-D-glucosaminyl) asparagine residue to N-acetyl-beta-D-glucosaminylamine and a peptide containing an aspartate residue. The encoded enzyme may play a role in the proteasome-mediated degradation of misfolded glycoproteins. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NGLY1 Add / Edit NGLY1: Annotations

No community annotations yet for NGLY1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NGLY1 is highly significantly mutated in
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NGLY1 is significantly mutated in
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NGLY1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NGLY1