NFYB Back

nuclear transcription factor Y, beta

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NCBI Description of NFYB
The protein encoded by this gene is one subunit of a trimeric complex, forming a highly conserved transcription factor that binds with high specificity to CCAAT motifs in the promoter regions in a variety of genes. This gene product, subunit B, forms a tight dimer with the C subunit, a prerequisite for subunit A association. The resulting trimer binds to DNA with high specificity and affinity. Subunits B and C each contain a histone-like motif. Observation of the histone nature of these subunits is supported by two types of evidence; protein sequence alignments and experiments with mutants.

Community Annotation of NFYB Add / Edit NFYB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFYB is highly significantly mutated in
(none)
NFYB is significantly mutated in
(none)
NFYB is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFYB