NFKBIZ Back

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, zeta

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NCBI Description of NFKBIZ
This gene is a member of the ankyrin-repeat family and is induced by lipopolysaccharide (LPS). The C-terminal portion of the encoded product which contains the ankyrin repeats, shares high sequence similarity with the I kappa B family of proteins. The latter are known to play a role in inflammatory responses to LPS by their interaction with NF-B proteins through ankyrin-repeat domains. Studies in mouse indicate that this gene product is one of the nuclear I kappa B proteins and an activator of IL-6 production. Two transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFKBIZ is highly significantly mutated in
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NFKBIZ is significantly mutated in
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NFKBIZ is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFKBIZ