NFKBIB Back

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, beta

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NCBI Description of NFKBIB
The protein encoded by this gene belongs to the NF-kappa-B inhibitor family, which inhibit NF-kappa-B by complexing with, and trapping it in the cytoplasm. Phosphorylation of serine residues on these proteins by kinases marks them for destruction via the ubiquitination pathway, thereby allowing activation of the NF-kappa-B, which translocates to the nucleus to function as a transcription factor. Alternatively spliced transcript variants have been found for this gene.

Community Annotation of NFKBIB Add / Edit NFKBIB: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFKBIB is highly significantly mutated in
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NFKBIB is significantly mutated in
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NFKBIB is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFKBIB