NFKBIA Back

nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha

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NCBI Description of NFKBIA
This gene encodes a member of the NF-kappa-B inhibitor family, which contain multiple ankrin repeat domains. The encoded protein interacts with REL dimers to inhibit NF-kappa-B/REL complexes which are involved in inflammatory responses. The encoded protein moves between the cytoplasm and the nucleus via a nuclear localization signal and CRM1-mediated nuclear export. Mutations in this gene have been found in ectodermal dysplasia anhidrotic with T-cell immunodeficiency autosomal dominant disease.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFKBIA is highly significantly mutated in
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NFKBIA is significantly mutated in
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NFKBIA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFKBIA