NFE2L3 Back

nuclear factor (erythroid-derived 2)-like 3

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NCBI Description of NFE2L3

This gene encodes a member of the cap 'n' collar basic-region leucine zipper family of transcription factors. The encoded protein heterodimerizes with small musculoaponeurotic fibrosarcoma factors to bind antioxidant response elements in target genes. This protein is a membrane bound glycoprotein that is targeted to the endoplasmic reticulum and the nuclear envelope. Pseudogenes of this gene are found on chromosomes 16, 17, and 18.

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NFE2L3 is highly significantly mutated in
NFE2L3 is significantly mutated in
NFE2L3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NFE2L3