NFATC2 Back

nuclear factor of activated T-cells, cytoplasmic, calcineurin-dependent 2

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NCBI Description of NFATC2
This gene is a member of the nuclear factor of activated T cells (NFAT) family. The product of this gene is a DNA-binding protein with a REL-homology region (RHR) and an NFAT-homology region (NHR). This protein is present in the cytosol and only translocates to the nucleus upon T cell receptor (TCR) stimulation, where it becomes a member of the nuclear factors of activated T cells transcription complex. This complex plays a central role in inducing gene transcription during the immune response. Alternate transcriptional splice variants encoding different isoforms have been characterized.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFATC2 is highly significantly mutated in
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NFATC2 is significantly mutated in
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NFATC2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFATC2