NFAT5 Back

nuclear factor of activated T-cells 5, tonicity-responsive

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NCBI Description of NFAT5
The product of this gene is a member of the nuclear factors of activated T cells family of transcription factors. Proteins belonging to this family play a central role in inducible gene transcription during the immune response. This protein regulates gene expression induced by osmotic stress in mammalian cells. Unlike monomeric members of this protein family, this protein exists as a homodimer and forms stable dimers with DNA elements. Multiple transcript variants encoding different isoforms have been found for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NFAT5 is highly significantly mutated in
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NFAT5 is significantly mutated in
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NFAT5 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NFAT5