NET1 Back

neuroepithelial cell transforming gene 1

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NCBI Description of NET1

This gene is part of the family of Rho guanine nucleotide exchange factors. Members of this family activate Rho proteins by catalyzing the exchange of GDP for GTP. The protein encoded by this gene interacts with RhoA within the cell nucleus and may play a role in repairing DNA damage after ionizing radiation. Pseudogenes of this gene are located on the long arms of chromosomes 1, 7 and 18. Alternative splicing results in multiple transcript variants that encode different protein isoforms.

Community Annotation of NET1 Add / Edit NET1: Annotations

No community annotations yet for NET1.
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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NET1 is highly significantly mutated in
NET1 is significantly mutated in
NET1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NET1