NEK8 Back

NIMA (never in mitosis gene a)- related kinase 8

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NCBI Description of NEK8
This gene encodes a member of the serine/threionine protein kinase family related to NIMA (never in mitosis, gene A) of Aspergillus nidulans. The encoded protein may play a role in cell cycle progression from G2 to M phase. Mutations in the related mouse gene are associated with a disease phenotype that closely parallels the juvenile autosomal recessive form of polycystic kidney disease in humans.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NEK8 is highly significantly mutated in
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NEK8 is significantly mutated in
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NEK8 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NEK8