NEK2 Back

NIMA (never in mitosis gene a)-related kinase 2

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NCBI Description of NEK2
This gene encodes a serine/threonine-protein kinase that is involved in mitotic regulation. This protein is localized to the centrosome, and undetectable during G1 phase, but accumulates progressively throughout the S phase, reaching maximal levels in late G2 phase. Alternatively spliced transcript variants encoding different isoforms with distinct C-termini have been noted for this gene.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NEK2 is highly significantly mutated in
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NEK2 is significantly mutated in
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NEK2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NEK2