NEFM Back

neurofilament, medium polypeptide 150kDa

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NEFM

Neurofilaments are type IV intermediate filament heteropolymers composed of light, medium, and heavy chains. Neurofilaments comprise the axoskeleton and functionally maintain neuronal caliber. They may also play a role in intracellular transport to axons and dendrites. This gene encodes the medium neurofilament protein. This protein is commonly used as a biomarker of neuronal damage. Alternative splicing results in multiple transcript variants encoding distinct isoforms.

Community Annotation of NEFM Add / Edit NEFM: Annotations

No community annotations yet for NEFM.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NEFM is highly significantly mutated in
(none)
NEFM is significantly mutated in
(none)
NEFM is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for NEFM