NDUFB3 Back

NADH dehydrogenase (ubiquinone) 1 beta subcomplex, 3, 12kDa

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NCBI Description of NDUFB3
This gene encodes an accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which is the first enzyme in the electron transport chain of mitochondria. This protein localizes to the inner membrane of the mitochondrion as a single-pass membrane protein. Mutations in this gene contribute to mitochondrial complex 1 deficiency. Alternative splicing results in multiple transcript variants encoding the same protein. Humans have multiple pseudogenes of this gene.

Community Annotation of NDUFB3 Add / Edit NDUFB3: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NDUFB3 is highly significantly mutated in
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NDUFB3 is significantly mutated in
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NDUFB3 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NDUFB3