NDUFAF4 Back

NADH dehydrogenase (ubiquinone) complex I, assembly factor 4

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NCBI Description of NDUFAF4
NADH:ubiquinone oxidoreductase (complex I) catalyzes the transfer of electrons from NADH to ubiquinone (coenzyme Q) in the first step of the mitochondrial respiratory chain, resulting in the translocation of protons across the inner mitochondrial membrane. This gene encodes a complex I assembly factor. Mutations in this gene are a cause of mitochondrial complex I deficiency. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NDUFAF4 is highly significantly mutated in
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NDUFAF4 is significantly mutated in
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NDUFAF4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NDUFAF4