NDRG4 Back

NDRG family member 4

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NCBI Description of NDRG4

This gene is a member of the N-myc downregulated gene family which belongs to the alpha/beta hydrolase superfamily. The protein encoded by this gene is a cytoplasmic protein that is required for cell cycle progression and survival in primary astrocytes and may be involved in the regulation of mitogenic signalling in vascular smooth muscles cells. Alternative splicing results in multiple transcripts encoding different isoforms.

Community Annotation of NDRG4 Add / Edit NDRG4: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NDRG4 is highly significantly mutated in
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NDRG4 is significantly mutated in
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NDRG4 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for NDRG4