NCR3 Back

natural cytotoxicity triggering receptor 3

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NCBI Description of NCR3

The protein encoded by this gene is a natural cytotoxicity receptor (NCR) that may aid NK cells in the lysis of tumor cells. The encoded protein interacts with CD3-zeta (CD247), a T-cell receptor. A single nucleotide polymorphism in the 5' untranslated region of this gene has been associated with mild malaria suceptibility. Three transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NCR3 Add / Edit NCR3: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NCR3 is highly significantly mutated in
NCR3 is significantly mutated in
NCR3 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NCR3