NCOR2 Back

nuclear receptor co-repressor 2

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NCBI Description of NCOR2
This gene encodes a nuclear receptor co-repressor that mediates transcriptional silencing of certain target genes. The encoded protein is a member of a family of thyroid hormone- and retinoic acid receptor-associated co-repressors. This protein acts as part of a multisubunit complex which includes histone deacetylases to modify chromatin structure that prevents basal transcriptional activity of target genes. Aberrant expression of this gene is associated with certain cancers. Alternate splicing results in multiple transcript variants encoding different isoforms.

Community Annotation of NCOR2 Add / Edit NCOR2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NCOR2 is highly significantly mutated in
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NCOR2 is significantly mutated in
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NCOR2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NCOR2