NBR1 Back

neighbor of BRCA1 gene 1

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NCBI Description of NBR1
The protein encoded by this gene was originally identified as an ovarian tumor antigen monitored in ovarian cancer. The encoded protein contains a B-box/coiled coil motif, which is present in many genes with transformation potential, but the function of this protein is unknown. This gene is located on a region of chromosome 17q21.1 that is in close proximity to tumor suppressor gene BRCA1. Three alternatively spliced variants encoding the same protein have been identified for this gene.

Community Annotation of NBR1 Add / Edit NBR1: Annotations

No community annotations yet for NBR1.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NBR1 is highly significantly mutated in
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NBR1 is significantly mutated in
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NBR1 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NBR1