NAT2 Back

N-acetyltransferase 2 (arylamine N-acetyltransferase)

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NCBI Description of NAT2

This gene encodes an enzyme that functions to both activate and deactivate arylamine and hydrazine drugs and carcinogens. Polymorphisms in this gene are responsible for the N-acetylation polymorphism in which human populations segregate into rapid, intermediate, and slow acetylator phenotypes. Polymorphisms in this gene are also associated with higher incidences of cancer and drug toxicity. A second arylamine N-acetyltransferase gene (NAT1) is located near this gene (NAT2).

Community Annotation of NAT2 Add / Edit NAT2: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NAT2 is highly significantly mutated in
NAT2 is significantly mutated in
NAT2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NAT2