NAT1 Back

N-acetyltransferase 1 (arylamine N-acetyltransferase)

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NCBI Description of NAT1

This gene is one of two arylamine N-acetyltransferase (NAT) genes in the human genome, and is orthologous to the mouse and rat Nat2 genes. The enzyme encoded by this gene catalyzes the transfer of an acetyl group from acetyl-CoA to various arylamine and hydrazine substrates. This enzyme helps metabolize drugs and other xenobiotics, and functions in folate catabolism. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of NAT1 Add / Edit NAT1: Annotations

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Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


NAT1 is highly significantly mutated in
NAT1 is significantly mutated in
NAT1 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for NAT1