NAGS Back

N-acetylglutamate synthase

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of NAGS
The N-acetylglutamate synthase gene encodes a mitochondrial enzyme that catalyzes the formation of N-acetylglutamate (NAG) from glutamate and acetyl coenzyme-A. NAG is a cofactor of carbamyl phosphate synthetase I (CPSI), the first enzyme of the urea cycle in mammals. This gene may regulate ureagenesis by altering NAG availability and, thereby, CPSI activity. Deficiencies in N-acetylglutamate synthase have been associated with hyperammonemia.

Community Annotation of NAGS Add / Edit NAGS: Annotations

No community annotations yet for NAGS.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NAGS is highly significantly mutated in
(none)
NAGS is significantly mutated in
(none)
NAGS is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NAGS