NACA Back

nascent polypeptide-associated complex alpha subunit

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NCBI Description of NACA
The protein encoded by this gene associates with basic transcription factor 3 (BTF3) to form the nascent polypeptide-associated complex (NAC). NAC binds to nascent proteins as they emerge from the ribosome, blocking interaction with the signal recognition particle (SRP) and preventing mistranslocation to the endoplasmic reticulum. However, nascent proteins with an exposed signal peptide will not be bound by the encoded protein, enabling them to bind the SRP and enter the secretory pathway. This protein has been determined to be an IgE autoantigen in atopic dermatitis patients. Several transcript variants encoding two different isoforms have been found for this gene.

Community Annotation of NACA Add / Edit NACA: Annotations

No community annotations yet for NACA.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NACA is highly significantly mutated in
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NACA is significantly mutated in
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NACA is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NACA