NAB2 Back

NGFI-A binding protein 2 (EGR1 binding protein 2)

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NCBI Description of NAB2
This gene encodes a member of the family of NGFI-A binding (NAB) proteins, which function in the nucleus to repress transcription induced by some members of the EGR (early growth response) family of transactivators. NAB proteins can homo- or hetero-multimerize with other EGR or NAB proteins through a conserved N-terminal domain, and repress transcription through two partially redundant C-terminal domains. Transcriptional repression by the encoded protein is mediated in part by interactions with the nucleosome remodeling and deactylase (NuRD) complex. Alternatively spliced transcript variants have been described, but their biological validity has not been determined.

Community Annotation of NAB2 Add / Edit NAB2: Annotations

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

NAB2 is highly significantly mutated in
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NAB2 is significantly mutated in
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NAB2 is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for NAB2