MYOZ2 Back

myozenin 2

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MYOZ2

The protein encoded by this gene belongs to a family of sarcomeric proteins that bind to calcineurin, a phosphatase involved in calcium-dependent signal transduction in diverse cell types. These family members tether calcineurin to alpha-actinin at the z-line of the sarcomere of cardiac and skeletal muscle cells, and thus they are important for calcineurin signaling. Mutations in this gene cause cardiomyopathy familial hypertrophic type 16, a hereditary heart disorder. Sequence Note: This RefSeq record was created from transcript and genomic sequence data to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on transcript alignments.

Community Annotation of MYOZ2 Add / Edit MYOZ2: Annotations

No community annotations yet for MYOZ2.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MYOZ2 is highly significantly mutated in
MYOZ2 is significantly mutated in
MYOZ2 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MYOZ2