MYO9B Back

myosin IXB

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NCBI Description of MYO9B
This gene encodes a member of the myosin family of actin-based molecular motor heavy chain proteins. The protein represents an unconventional myosin; it should not be confused with the conventional non-muscle myosin-9 (MYH9). The protein has four IQ motifs located in the neck domain that bind calmodulin, which serves as a light chain. The protein complex has a single-headed structure and exhibits processive movement on actin filaments toward the minus-end. The protein also has rho-GTPase activity. Polymorphisms in this gene are associated with celiac disease and ulcerative colitis susceptibility. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MYO9B Add / Edit MYO9B: Annotations

No community annotations yet for MYO9B.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MYO9B is highly significantly mutated in
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MYO9B is significantly mutated in
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MYO9B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MYO9B