MYL12B Back

myosin, light chain 12B, regulatory

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NCBI Description of MYL12B
The activity of nonmuscle myosin II (see MYH9; MIM 160775) is regulated by phosphorylation of a regulatory light chain, such as MRLC2. This phosphorylation results in higher MgATPase activity and the assembly of myosin II filaments (Iwasaki et al., 2001 [PubMed 11942626]).[supplied by OMIM, Mar 2008].

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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MYL12B is highly significantly mutated in
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MYL12B is significantly mutated in
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MYL12B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MYL12B