MUC5B Back

mucin 5B, oligomeric mucus/gel-forming

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NCBI Description of MUC5B
This gene encodes a member of the mucin family of proteins, which are highly glycosylated macromolecular components of mucus secretions. This family member is the major gel-forming mucin in mucus. It is a major contributor to the lubricating and viscoelastic properties of whole saliva, normal lung mucus and cervical mucus. This gene has been found to be up-regulated in some human diseases, including sinus mucosa of chronic rhinosinusitis (CRS), CRS with nasal polyposis, chronic obstructive pulmonary disease (COPD) and H. pylori-associated gastric disease, and it may be involved in the pathogenesis of these diseases. Sequence Note: The RefSeq transcript and protein were derived from genomic sequence to make the sequence consistent with the reference genome assembly. The genomic coordinates used for the transcript record were based on partial transcript alignments that tile across this locus.

Community Annotation of MUC5B Add / Edit MUC5B: Annotations

No community annotations yet for MUC5B.
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Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MUC5B is highly significantly mutated in
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MUC5B is significantly mutated in
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MUC5B is near significance in
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Click on a tumor type to see its full list of significant genes.

Data details


• Mutation list for MUC5B