MUC4 Back

mucin 4, cell surface associated

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MUC4

The major constituents of mucus, the viscous secretion that covers epithelial surfaces such as those in the trachea, colon, and cervix, are highly glycosylated proteins called mucins. These glycoproteins play important roles in the protection of the epithelial cells and have been implicated in epithelial renewal and differentiation. This gene encodes an integral membrane glycoprotein found on the cell surface, although secreted isoforms may exist. At least two dozen transcript variants of this gene have been found, although for many of them the full-length transcript has not been determined or they are found only in tumor tissues. This gene contains a region in the coding sequence which has a variable number (>100) of 48 nt tandem repeats.

Community Annotation of MUC4 Add / Edit MUC4: Annotations

No community annotations yet for MUC4.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes

• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


MUC4 is highly significantly mutated in
MUC4 is significantly mutated in
MUC4 is near significance in

Click on a tumor type to see its full list of significant genes.

Data details

Mutation list for MUC4