MUC20 Back

mucin 20, cell surface associated

External References:      Wikipedia GeneCards HUGO COSMIC Google Scholar

NCBI Description of MUC20

This gene encodes a member of the mucin protein family. Mucins are high molecular weight glycoproteins secreted by many epithelial tissues to form an insoluble mucous barrier. The shorter isoform expressed by this gene is localized to the plasma membrane, whereas the longer isoform might be secreted. The C terminus of this protein associates with the multifunctional docking site of the met proto-oncogene and suppresses activation of some downstream met signaling cascades. The protein features a tandem repeat domain that varies between 2 and 6 copies in most individuals. The allele represented in the human reference assembly contains 12 copies. Multiple transcript variants encoding different isoforms have been found for this gene.

Community Annotation of MUC20 Add / Edit MUC20: Annotations

No community annotations yet for MUC20.
Sort mutations by: Tumor type  Mutation type  Position  
Straightedge cursor Expand

Figure notes


• "Mouse over" a mutation to see details.
• Missense green saturation indicates evolutionary conservation of the mutated positions.
• Red hashes in protein strip are splice sites.
• Blue-white-red bars are log2 copy ratio distributions (–1 to +1) from Zack et al. (2013).


Legend

MUC20 is highly significantly mutated in
(none)
MUC20 is significantly mutated in
(none)
MUC20 is near significance in
(none)

Click on a tumor type to see its full list of significant genes.

Data details


Mutation list for MUC20